Abstract: The average operating depth of deepwater Oilfield A in West Africa is 1 500 to 1 700 m. The oilfield is developed by six series of strata. The production wells adopt three sand prevention measures of frac-pack, expandable screen pipe, and high-quality screen pipe. By analyzing the properties of oil reservoir and the actual production data of development wells, the effects of the three sand prevention methods are evaluated from three aspects of sand controlling result, skin factors, and single well productivity. The research results show that all of the three methods can effectively prevent sand under a reasonable production system; to analyze from reducing skin factors and increasing well productivity, high-quality screen pipe is more advantageous in the region; frac-pack can withstand greater differential pressure of production.