Abstract: The ultra-deep wells in the Guangming Structure of the Hetao Basin commonly face technical challenges including complex pressure systems, narrow safe mud density windows, poor well stability, low rock drillability in localized formations, and high well control risks. These issues often lead to complex downhole events such as kicks, losses, collapses, and stuck pipe, resulting in low drilling efficiency and prolonged cycle times. On this basis, Abnormal-pressure mechanisms were clarified, and a three-pressure (pore-fracture-collapse) profile was built with a multi-factor geomechanical model. This guided the optimization of casing programs, eliminating the historic upper lost-circulation, lower influx problem in the same open-hole section. Using rock-mechanical-property profiles, customized PDC bits and high-torque screw acceleration tools were selected, and drilling parameters were optimized to raise ROP. Based on the understanding of formation dip angle and the anti-inclination effect of large-sized well pendulum drilling tool combination, the anti inclination and fast drilling technology of vertical drilling tool matching screw is recommended. Based on stability analysis of high-pressure water-bearing formations and contamination tests, the innovative managed-pressure water-out safe drilling technique was introduced, sharply reducing both mud losses and loss events. Considering salt/gypsum distributions and creep laws, an oil-based mud system was chosen, supported by managed-pressure drilling and salt/gypsum-safe techniques, effectively controlling sticking and tight-spot risks. The combined technology was field-tested in three wells. Average drilling cycle dropped from 322 days to 195 days, a 39.44% reduction, markedly accelerating efficient exploration and development. The effort also provides valuable experience for future ultra-deep drilling acceleration across the Hetao Basin.