Abstract: Due to the influence of intensive tectonic compression on folded belts in Bayn, Hetao Basin, the rock mechanics properties vary across different directions, resulting in frequent downhole complications during drilling. In order to improve the accuracy of rock mechanics parameters calculation and reveal the stress distribution patterns in deep strata, based on the assumption of anisotropy, through analogy and simplification of the relationship between rock ultrasonic test experiment and formation acoustic logging, combined with the differential response of sandstone and mudstone to tectonic compression, a micro-element model for sandy-muddy strata was developed to evaluate the formation anisotropy characteristics. At the same time, the stress-strain constitutive equation was adopted to calculate the anisotropic rock mechanics parameters, and the Thiercelin model was introduced to draw the anisotropic in-situ stress profiles. The model prediction results were validated by triaxial compression tests and acoustic emission Kaiser experiments. The results show that after entering the intensive tectonically compressed stratum, the horizontal maximum principal stress exceeds the overburden pressure and becomes the dominant factor controlling rock mechanics properties, and the lateral rock mechanics properties are enhanced. Maintaining the direction of dynamic and static rock mechanics parameters consistent, the established anisotropic mechanics parameters conversion model is more suitable for intensive tectonically compressed strata. Compared with the traditional isotropic in-situ stress calculation models, the anisotropic model based on acoustic time difference logging can more accurately reflect the variation law of in-situ stress with depth, and the prediction accuracy is improved by 8.22%. The established anisotropic in-situ stress calculation method provides a reliable theoretical basis and engineering guidance for safe and efficient drilling in intensive tectoniccally compressed formations.