Abstract: Pressure measurement while drilling technology enables acquisition of real-time formation pressure during the drilling process and computation of formation mobility based on pressure response curves. However, the mobility values computed from pressure measurement while drilling results are generally underestimated due to multiple factors such as pumping mode, formation anisotropy, and hole deviation angle, and the key influencing factors remain unclear. To address these issues, a finite element theoretical model for thermal-fluid coupling numerical simulation of pressure measurement while drilling in deviated wells was established. The dimensionless Spearman correlation analysis method was employed to systematically identify the critical factors affecting mobility derived from pressure measurement while drilling in deviated wells, and a corresponding mobility correction method was proposed. The accuracy of the model and simulation approach was verified through laboratory experiments. The hole deviation angle, permeability anisotropy ratio, tool face orientation,and formation-to-wellbore temperature difference are determined as the dominant factors influencing mobility computations from pressure measurement while drilling. The mobility correction method is validated with field cases, showing significant effectiveness. This research provides a solid theoretical foundation and technical support for the optimization of devices for pressure measurement while drilling.