Abstract: Through many years’ studying and field practicing, a series matching technologies were formed according to the problems coming forth in the low permeability pools development such as low static pressure, low production, low liquid level, casing failure and oil well scaling. These technologies include drilling technology of directional well and cluster wells, optimize perforation technology, fracturing technology, optimize design and computer diagnosis of directional well pipe string. They also include formation damage prevention technology, technology of integration father in casing failure well, technology of drugging viscosity reducing in wellhead, injection increase technology and so on. These technologies availably improved the development benefit of low permeability pools.