Abstract: An experimental study was carried out to determine the relations among rock permeability, porosity (compression coefficient) and effective stress, and to drive a state equation. The station equation can be used in setting up single well one dimensional two phase radial flow model whose boundary value problem can be worked out by a three dimensional two phase numerical model. By the flow principle in nearby well of low-permeability stratum under varied stress conditions can be further studied, and IPR curves of single well can also be plotted. It was also discussed that the radial flow model was used in interpreting oil field production data. Therefore, studying reservoir sensibility by experimental approach and computer models in doing with oil field production data were practicable and reasonable.