Abstract: In the course of cementation, slurry filtrate and cement fine grains will greatly enter into hydrocarbon reservoir, then block oil and gas channels and directly influence the effect of oil and gas production if the property of slurry can’t be adjusted and controlled. The influence of slurry filtrate on rocky permeability was analyzed through test. The rocky permeability damage tests were taken for the homogeneous rock in the slurry systems which have different water loss at the same condition, and the best control scope of the slurry filtrate loss was found. The field application indicates that the water loss of slurry should be controlled no more than 70 mL in the cementation. The research is instructive for protecting hydrocarbon reservoir comparatively in the cementing and raising the production of oil well.