Abstract: During plug of perforation, grout has disadvantages such as high risk, prolonged period of work and severe contamination of grout to reservoir, so a perforation-plugging agent (FD-1) of compound resin was developed. Due to some dissolvable fiber and oil-solubility substance were added to the grout, FD-1 has less contamination to the oil formation. It is proved to be better for plugging when it is used together with heal agent. With long hardening time and uneasy to freeze. The compressing intensity of FD-1 reached to 16 MPa. The agent do not plug on the well during the work. The plugging rate to different rock exceeds 95%. The recovery of oil permeability exceeds 50%. Applications of FD-1 shows that the agent adequate to plug perforation and big holes in well.