Abstract: Based on the research on the law of profile parameter and drift velocity of drift model for two-phase flow in vertical pipeline, theoretical analysis and experimental researches are done to propose the expressions of profile parameter and drift velocity of drift model for two-phase flow in horizontal pipeline, which include four unknown constant parameters. According to the data of multiphase flow experiment in simulation test section of horizontal wellbore, Parameter Optimization Method is used to solve the constant parameters. Finally, complete drift-flux model on two-phase flow in horizontal wellbore is developed.