Abstract: ZM-351 is one experimental surface casing drilling well with diameter of 339.7 mm, which is located in block CAMPO MATA, Anaco Oil Filed of PDVSA. The well adopts the advanced international casing drilling technology, i.e. top drill lock assembly bottom drill lock device. Compared with the close wells that are the same well structure and at the same block, the ZM-351 well completion time is shortened, the cost is reduced, and fully showing the advantage of casing drilling. The thesis describes ZM-351 casing drilling process, casing drilling key technology, drilling rig selection and its accessories and etc. so as to provide some experience for casing drilling in China.