Abstract: Multi-hydrogen acid is characterized by retarding, deep penetrating, scale prevention, great adsorption capacity and water wettability, which is suitable for blocking removal of sandstone reservoir by catalyzing the chemical reaction between hydrofluoric acid and quartz. Based on the analysis of damage reason for loe permeability reservoir, the mechanism, characteristics and treatment fluid function of multi-hydrogen acidizing blocking removal technology were detail illustrated in this paper, and then the example of field application was analyzed. The result showed that multi-hydrogen acidizing blocking removal technology bought great effect in low permeability reservoir development.