Abstract: To accelerate gas field development of Daniudi field using horizontal well pattern, considering the demand of He-1 gas layer stimulation, well pattern fracturing mode study is conducted, based on horizontal well sectional fracturing technique with multi-stage packers. Through optimizing fracturing design, the design parameters are adjusted real-time combined with the operation parameters and fracture monitoring results, and the cluster horizontal wells “well plant” fracturing mode is formed. Field applications are conducted on the 6 horizontal wells in R pattern, with the result of 77.88×104 m3/d as absolute open flow rate. The study explores successfully the effective method to develop tight sand gas reservoirs by horizontal well fracturing.